聯亞疫苗擠身全球10個受關注的高潛能二代疫苗選手!
4月29日,Clinical Trials Arena (臨床試驗論壇——一個為高階專業人士提供全球臨床試驗市場相關新聞、觀點和趨勢的平台)發表一篇名為「10個下一代新冠肺炎疫苗選手 」(10 next-gen Covid-19 vaccines in the race for approval)的分析,聯亞研發中的疫苗,擠身受關注的這十大高潛能疫苗之一!
二代疫苗因為第一代疫苗的副作用連連,而備受期待!
報告內容中說:
與武漢肺炎的戰爭仍然在持續中,雖然目前一線藥廠已紛紛推出有效疫苗,但無論AZ、嬌生、BNT,在世界各地都有傳出副作用,例如血栓或是心肌炎等。世界因此轉向注意那些研發速度較慢,但製作方法比較不一樣的疫苗。
本文列出10個WHO登記有案的疫苗,已進入最後階段的高潛能疫苗供參。
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Vaxxinity (聯亞)
Candidate name: UB-612
這支疫苗能同時活化T細胞跟B細胞,強化全面免疫能力。在台灣進行的實驗收取第一期60人,第二期3850人。
一期研究表明 UB-612 的安全性、耐受性和免疫原性的評估結果,發現該疫苗通常具有良好的耐受性,並引發了強烈的疫苗誘導的 CD4+/CD8+ T 細胞抗體反應。
Vaxxinity 也已和醫療公司 Dasa 合作在巴西進行 II/III 期試驗,並與內布拉斯加大學合作在美國進行 I/II 期試驗。
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以上是內容摘要。
全世界還有一百多個疫苗在研發,能夠被關注,視為十個臨床試驗中的高潛能選手之一,表示是一個值得期待的二代疫苗。雖然結果還在未定之天,但是至少我們不必妄自菲薄!
台灣的反對黨在國產疫苗的政策鬥爭中,詆毀國產疫苗的公信力,和國際產業科學形容國產疫苗的高潛能,形成了諷刺的對比!
台灣需要發展疫苗產業,不只如此,醫藥生技產業急起直追,從中國鎖藥危機中,取回我們的「醫藥主權」、「疫苗主權」,已經是國安戰略的問題。
根據「今周刊」的報導,除了
B N T疫苗,中資取得台灣授權的藥物,包括抗生素、癌症用藥等,高達130種之多。這問題呈現的非常清楚,中國正利用商業手段,促成「醫統」,企圖用鎖藥、鎖疫苗, 逼我們就範、引我們內亂;這次讓我們買不到BNT疫苗,赤裸裸的演習了一次,政府被逼得束手無策,最後美、日出手相助,過程的紛亂,餘悸猶存!
今天提供這個資料,是希望大家拉出一個全球比較的視野,平等的看待國產疫苗。
Mechanism: Multitope peptide-based vaccine
Trial phase: Phase II/III
Vaxxinity (formerly COVAXX), a subsidiary of United Biomedical (UBI), is developing UB-612, a multitope protein/synthetic peptide-based vaccine candidate for Covid-19. UB-612 is designed to activate both T-cell and B-cell immunity in the body and has shown neutralising antibody activity in mice, rats, and guinea pigs.
In Taiwan, a Phase I trial of up to 60 participants is underway, and a Phase II trial of 3,850 participants has been initiated.
Results from the Phase I study, which evaluated the safety, tolerability, and immunogenicity of UB-612, showed that the vaccine was generally well-tolerated and elicited robust vaccine-induced CD4+/CD8+ T cell antibody responses.
Vaxxinity is also partnering with medical company Dasa for a Phase II/III trial in Brazil, and with the University of Nebraska for Phase I/II trials in the United States.
https://www.clinicaltrialsarena.com/analysis/10-next-gen-covid-19-vaccines-in-the-race-for-approval/?fbclid=IwAR1EMGP5RBoJ0oX_KCMhgAVLG-hV2sVQDN4SAaGK80beBqAjJR_mX-4RxBU
同時也有8部Youtube影片,追蹤數超過16萬的網紅Sneaky Sushii,也在其Youtube影片中提到,these are my thoughts on the whole City Revival issue. like and sub if you're cool :) turn on post notifs if you're feeling freaky? my instagram: ht...
showed shown 在 媽媽監督核電廠聯盟 Facebook 的最讚貼文
輻射傷害的防護基本理念: ALARA (As Low As Reasonably Achievable),受曝劑量越低越好的合理抑低原則。
在輻射傷害防護的範疇內,總的來說,LNT(Linear-Non-Threshold)模式對於高劑量、高強度的輻射暴露的情況相對來說,更加的適用。在一般日常生活的狀態來說,避免輻射傷害,普遍採取 ALARA( As Low As Reasonably Achievable),也就是越低越好的合理抑低原則,這是人類關於游離輻射防護的基本理念。
ALARA( As Low As Reasonably Achievable; 越低越好的合理抑低 )原則也是美國能源部國家核子保安總署(DOE/NNSA)輻射 緊急事件支援及訓練中心(REAC/TS)出版之「The Medical Aspects of Radiation Incidents (台灣翻譯為:輻射傷害醫療處置)」手冊內容中所提及的輻射防護基本理念。
“ALARA (As Low As Reasonably Achievable) is the underlying philosophy associated with protecting people from ionizing radiation.
It basically means that one should not unnecessarily expose themselves to radiation without the benefit outweighing the risk.
Time, distance, andshielding are widely considered to be the primary
concerns. At REAC/TS, we like to add a fourth item to the list - quantity. All four of these concepts are used concurrently with the others. "
其基本意涵是 : 一個人應該避免不必要且無利益的輻射 曝露風險(這裡指的是非醫療性質的輻射暴露。任何輻射暴露都會造成傷害,但在治療重大疾病的時候,兩害相權取其輕,接受有限度且嚴格控管的輻射照射將體內惡性病變組織破壞,阻止其增生、擴散惡化的潛在利益大於輻射照射所引起的傷害的醫療應用案例,不屬於這裡所指的“不必要且無利益的輻射曝露風險”的範疇)。
此外,有報導指出:“...... 在日本的實際研究案例中,「餵飲氘水佔1/3的水,經過1個禮拜,老鼠腦部組織裡的氫被替換掉,老鼠變得眼睛上吊,有攻擊性,一直囓咬鐵籠的鐵網,反覆地昏睡或暴躁。」東京工業大學理工特任教授入口紀男(Norio Iriguchi),透過老鼠實驗,提醒福島氚污染水的危害。
入口紀男教授是日本核磁共振學會委員,透過上述實驗鼠的核磁共振影像,解說老鼠腦部組織內的氫被氘替換之後,所發生的變化。「左邊有點突出的是嗅腦(嗅覺發達中樞),右下突起的部份是延髓開端。目前只有腦部明顯地浮腫了。」
福島核災後,產生大量輻射污染水,其中氚因為無法用過濾去除,又稱為氚污染水。多位專家警告,氚污染水的危害,不只是體內輻射被曝,還有在體內被當成氫嵌入到蛋白質等組織的問題。而入口紀男(用有同樣效果的氘做)的實驗,具體呈現後者的狀況。
「氚在體內被當成氫嵌入」是什麼意思呢?擁有近40年的放射線治療經驗、北海道癌症中心名譽院長西尾正道詳細解釋道:「氚在人體內會被當成氫來代謝。人體有62%是水(H2O),氚會被當成氫來結合,在種種構成人體的高分子化合物的化學式裡也一樣。」
「氚因為有這樣和物質相結合的性質,在體內造成長期被曝。用醫學實驗,可以證明氚會被當成氫攝入到細胞核內。構成DNA的基因的4個鹽基,是靠氫來結合,換成氚進去的話(失去結合力),鹽基化學式產生變化,遺傳情報也會改變。導致健康上的實際損害。」而當被攝入的氚衰變成氦時,也會損傷細胞( http://www.inaco.co.jp/hiroshima_2_demo/pdf/20140103_tori_A4.pdf )。
對此,西尾正道等專家批判:「不能說自然界本來就有而不考慮,原本自然界裡氚的最大來源就是核試爆跟核電,排放標準也是為了沸水式原子爐把氚排到海裡而制定的,並不是因為有在科學上醫學上檢討健康被害而決定的。」「因為距離極近,即便氚的放射線弱,仍會相當程度地傷害DNA。」
又,氚水的化學式是HTO,因為氚很容易和生物體內的碳結合,成為有機結合型氚(Organically Bound Tritium、簡稱為OBT),跟氚水相比,後者滯留體內時間為20~50倍,被染色體等人體重要部份攝取。「氚水被放流後,經生物攝取變成有機結合型氚,人類去吃這些生物,便會蓄積在體內。」在核食檢測上,有機結合型氚的檢測程序,又比普通的氚來得複雜。
氚,被日本諾貝爾物理學獎得主小柴昌俊,與馬克斯威爾獎(美國物理學會頒發)得主長谷川晃,稱之為劇毒。
福島核電廠在災後,因為會不斷放出有放射性的蒸氣等污染,入口紀男比喻為「國土百萬年的惡夢」。而這惡夢除了往大氣的污染,還因為地下水流經,每天產生3-400噸的輻射污染水。
在日本政府規劃的輻射污染水處理方案裡,海放是成本最低的方法,比起地下埋設等耗資千億日圓以上的方法,海放只要17~34億日圓。另一方面民間、在地漁業團體與鄰國,持強烈反對的立場。....."
也有多項相關的醫學研究報告指出:
A 1961 experiment showed that mice dosed with 21.5 μCi/g of Cs-137 had a 50% fatality within 30 days (implying an LD50 of 245 μg/kg).
A similar experiment in 1972 showed that when dogs are subjected to a whole body burden of 3800 μCi/kg (140 MBq/kg, or approximately 44 μg/kg) of caesium-137 (and 950 to 1400 rads), they die within 33 days, while animals with half of that burden all survived for a year.
Important researches have shown a remarkable concentration of 137Cs in the exocrine cells of the pancreas, which are those most affected by cancer.
In 2003, in autopsies performed on 6 children dead in the polluted area near Chernobyl where they also reported a higher incidence of pancreatic tumors, Bandazhevsky found a concentration of 137Cs 40-45 times higher than in their liver, thus demonstrating that pancreatic tissue is a strong accumulator and secretor in the intestine of radioactive cesium.
一項重要的醫學研究發現,人體胰腺外分泌細胞中所聚積的137Cs濃度非常高,而胰腺外分泌細胞是受癌症影響最大的人體細胞。
在2003年由Bandazhevsky研究團隊,對六名生活在靠近車諾比核災污染區附近的兒童的屍體進行醫學檢驗解剖。
解剖研究發現這六名兒童患胰臟惡性腫瘤的比率,比一般正常狀態下來的更高,經檢驗,研究團隊發現這六名兒童胰臟中所含的Cs-137濃度,竟然是肝臟中所含Cs-137濃度的40-45倍之多。研究證實在人體內Cs-137最容易聚積在胰臟內。
胰臟癌是指胰臟細胞發生癌變而產生的腫瘤,這些腫瘤細胞具有侵犯其他組織的能力。胰臟癌很少發生在40歲以下的病人,半數以上的患者超過70歲。
此外,1961年的一項實驗發現對老鼠注射21.5 μCi/g 濃度的Cs-137,在30天之內有一半的受試老鼠死亡,這項實驗的結果等同於半至死劑量為0.000245公克(也就是百萬分之245公克),所謂半至死劑量指的是指在固定濃度下,暴露一定時間(通常1~4 小時)後,觀察14 天, 能使試驗動物組群半數(50 %)死亡的濃度。
在1972 年有另外一項類似的實驗, 對受試驗的狗群注射3800 μCi/kg (140 MBq/kg, or approximately 44 μg/kg,大約百萬分之44公克濃度)Cs-137,這群受試的狗在33天內全數死亡,而另一群接受一半劑量的受試狗群,則可以存活到為期一年。
從上述的那些實際醫學研究例證,包括了比較適用於LNT模式的狀態,以及一般日常生活環境下遭遇到低劑量但是長期輻射暴露累積下來的狀態。ALARA( As Low As Reasonably Achievable; 合理抑低 )原則在兩種狀態下通通一體適用。
參考資料:
https://orise.orau.gov/resources/reacts/documents/medical-aspects-of-radiation-incidents.pdf
http://www.inaco.co.jp/hiroshima_2_demo/pdf/20140103_tori_A4.pdf
https://e-info.org.tw/node/221554
^Moskalev, Yu. I. (1961). "Biological Effects of Cesium-137". In Lebedinskiĭ, A. V.; Moskalev, Yu. I. (eds.). Distribution, Biological Effects, and Migration of Radioactive Isotopes. Translation Series. United States Atomic Energy Commission (published April 1974). p. 220. AEC-tr-7512.
^ H.C. Redman; et al. (1972). "Toxicity of 137-CsCl in the Beagle. Early Biological Effects". Radiation Research. 50 (3): 629–648. Bibcode:1972RadR...50..629R. doi:10.2307/3573559. JSTOR 3573559. PMID 5030090.
^ Nelson A , Ullberg S, Kristoffersson H, Ronnback C (1961). "Distribution of Radiocesium in Mice". Acta Radiologica. 55, 5 (5): 374–384.
doi:10.3109/00016926109175132. PMID 13728254.
^ Bandazhevsky Y.I. (2003). "Chronic Cs-137 incorporation in children's organs". Swiss Med. Wkly. 133 (35–36): 488–90. PMID 14652805.
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showed shown 在 美國在台協會 AIT Facebook 的最讚貼文
美國在台協會向2021年4月2日太魯閣號列車事故中罹難的兩位傅爾布萊特英語教學助理表達深切的哀悼。美國在台協會處長酈英傑將一張館區內的長椅命名為傅爾布萊特長椅,並獻給兩位年輕美籍教師:駱盈盈與舒芮,紀念她們的熱忱、對學生和社群的奉獻,及她們留給我們的美好回憶。台灣傅爾布萊特計畫表示:「我們在世的時間有限,而駱盈盈與舒芮的時間卻太短促,但她們教會我們的是,無論時間長短,我們都應該對人生保持好奇,並常懷寬容及感激之心。」也許文字無法充分表達我們內心的沉痛,但我們在此向她們的親友,以及所有在這次事故中失去摯愛的人們致上最深的慰問。美國在台協會感謝台灣對駱盈盈與舒芮家屬的關心和妥善安排,並協助他們度過這艱難的時刻。我們謹以這張長椅向兩位美籍教師致敬,我們將永遠懷念她們的付出及奉獻。
https://www.fulbright.org.tw/in-loving-memory-of-our-fulbright-etas/
The American Institute in Taiwan mourns the passing of two Fulbright English Teaching Assistants (ETAs) in the Hualien train derailment on April 2, 2021. AIT Director Brent Christensen dedicated a Fulbright Bench to these two young women, Laura Luo and Senéad Short. We honor their loving memory, and their passion and commitment to their students and community. Fulbright Taiwan said “Our time in this world is finite. Laura’s and Senéad’s were too short. But they showed us that whatever the duration, we should fill our lives with curiosity, generosity, and gratitude.” Words may not suffice to express our heartfelt sorrow, and we extend our deepest condolences to all of the families and friends who lost loved ones in this tragic accident. AIT thanks Taiwan for the considerations and courtesies shown to the families of Laura and Senéad during this difficult period. This bench will help keep them in our hearts and minds, and serve as a lasting tribute to them for many years to come.
https://www.fulbright.org.tw/in-loving-memory-of-our-fulbright-etas/
showed shown 在 Sneaky Sushii Youtube 的最讚貼文
these are my thoughts on the whole City Revival issue.
like and sub if you're cool :) turn on post notifs if you're feeling freaky?
my instagram:
https://www.instagram.com/sneakysushii
thanks for watching bby.
*I just realised after posting that the address shown in the video was inaccurate. I think there's another church called City Revival? But just note that the location I showed is that of a different church!* JOIN THE DISCORD SERVER! ➤ https://discord.gg/GNepR9FeYV
![post-title](https://i.ytimg.com/vi/5kODirbV7Zg/hqdefault.jpg?sqp=-oaymwEbCKgBEF5IVfKriqkDDggBFQAAiEIYAXABwAEG&rs=AOn4CLDfA-yHLpFQ7GhO_eP9efUJ99wR_w)
showed shown 在 Saroop Roshi Youtube 的最讚貼文
HOW TO STYLE MINI SKIRTS EASILY OUTFITS IDEAS + LOOKBOOK
Lookbook starts at 1:48
Subscribe to my channel ❤️ ❤️ ❤️
...
Ep8:Style with Roshi.
?In this video, I showed some easy ways to style mini skirts outfit ideas. I separated those outfits into 4 different categories ;
1. Chic (2:38) which shows classy ways to style mini skirts
2. Clean and Casual (5:34) which shows how you can style basic tops with mini skirts
3. Casual (7:02) which shows how you can style a hoodie with a mini skirt
4. Add ons (8:55). In this category, i will be adding 3 different add ons to elevate your whole outfits which includes the blazer, leggings and knee high boots.
These outfits can be worn as college outfit ideas and even when you are back to school.?
#easywaystostyleminiskirtoutfutideas
#fashionLookbook
#5waystowear #easyAlineskirttutorial
?Outfits worn in this video :
✨Skirts (H&M)
✨white and black casual top (Uniqlo) ✨Hoodie (H&M)
✨Blazer (@360plus5)
✨Under knee high boots (@hidhashoes)
✨My apologies if any other outfits aren't mentioned, I just can't remember where I got them from since it's been a while. ?? And alot of them are thrifted.
?Videos mentioned
White shirt outfit ideas
✨https://youtu.be/E7WxucA7D3M
Turtle Neck top outfit ideas
✨https://youtu.be/_eqeUkUaFGw
Knee high boots outfit ideas
✨https://youtu.be/9ojZVZUWgYk
?About #StylewithRoshi #stylebynumbers
?Created new series where I will be doing alot of easy, classy, elegant and chic lookbooks and MORE lookbooks are on your way so please SUBSCRIBE to my channel and turn the notification bell on.?♀️
#stylewithme #stylebynumbers
?Tag me if you ever try it. ❤️
?Do comment down below if you want to see me filming,
Fashion lookbooks, Classy and elegant outfits lookbooks, chick outfits Lookbook , casual outfits lookbooks, business outfits ideas lookbooks, summer outfits , spring outfits, winter outfits lookbook, brown girl makeup tutorial, beginner makeup tutorial, vlogs or challenges videos.❤️
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?Say hi to me on my Social media:-
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Facebook page : Saroop Roshi
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[email protected]
Love yall❤️,
Saroop Roshi
Today in this video I showed some easy way to style mini skirts which also includes an easy ways to style mini skirts outfit ideas Lookbook. This video is suitable to those who need college mini skirts outfit ideas and back to school mini skirt outfit ideas. I also showed some classy ways to style mini skirts outfit ideas. I love how flexible you can be with mini skirts, because not only you can style it with fancy clothes but i showed some ways on how you can style mini skirt with basic tops. In this video, it is also shown how you can style hoodie with a mini skirt making it girly ways to style hoodie outfit ideas. This mini skirt and fashion Lookbook also includes skirts such as A line skirt, pleated and skater skirt. Hope you enjoyed and Subscribe to me.
?Music used
–––––––––––––––––––––––––
Music used:
The crown - Hard Trap Beat by Prod. Riddiman
Stream beats on:
Spotify: https://spoti.fi/2u4ZS7R
Apple Music: https://apple.co/2GIxb8j
Lakey inspired - Chill Day » SoundCloud: https://soundcloud.com/lakeyinspired
![post-title](https://i.ytimg.com/vi/2rhXLnQAVek/hqdefault.jpg)
showed shown 在 #ミニマリストライフ Youtube 的精選貼文
https://amzn.to/2GGERY3
ミニマリストやシンプルライフに代表される少ない物で生活すると言う知恵は今に始まったことではありません。私が見つけたネタで一番古い物はコナンドイルの『緋色の研究』です。あの、シャーロックホームズとワトソン博士が出会う話です。緋色の習作(Amazonアソシエイトプログラムを利用しています)
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誰も考えない切り口でシンプルな生き方を提案します。物を軽く少なくする「ミニマリスト」「シンプルライフ」の知恵を応用した動画を公開中。
This movie has Japanese caption for learn Japanese.
A Study in Scarlet Arthur Conan Doyle
CHAPTER II
THE SCIENCE OF DEDUCTION
"You appear to be astonished," he said, smiling at my expression of surprise. "Now that I do know it I shall do my best to forget it."
"To forget it!"
"You see," he explained, "I consider that a man's brain originally is like a little empty attic, and you have to stock it with such furniture as you choose. A fool takes in all the lumber of every sort that he comes across, so that the knowledge which might be useful to him gets crowded out, or at best is jumbled up with a lot of other things, so that he has a difficulty in laying his hands upon it. Now the skilful workman is very careful indeed as to what he takes into his brain attic. He will have nothing but the tools which may help him in doing his work, but of these he has a large assortment, and all in the most perfect order. It is a mistake to think that that little room has elastic walls and can distend to any extent. Depend upon it there comes a time when for every addition of knowledge you forget something that you knew before. It is of the highest importance, therefore, not to have useless facts elbowing out the useful ones."
"But the Solar System!" I protested.
"What the deuce is it to me?" he interrupted impatiently; "you say that we go round the sun. If we went round the moon it would not make a pennyworth of difference to me or to my work."
I was on the point of asking him what that work might be, but something in his manner showed me that the question would be an unwelcome one. I pondered over our short conversation, however, and endeavoured to draw my deductions from it. He said that he would acquire no knowledge which did not bear upon his object. Therefore all the knowledge which he possessed was such as would be useful to him; I enumerated in my own mind all the various points upon which he had shown me that he was exceptionally well-informed. I even took a pencil and jotted them down. I could not help smiling at the document when I had completed it. It ran in this way:—
https://www.youtube.com/watch?list=UURwqTcUh7jMWqFjSYH3JHow&v=sf6JWWxvFHM
#Organ_Life #オルガンライフ
ミニマリストやシンプルライフに代表される少ない物で生活すると言う知恵は今に始まったことではありません。私が見つけたネタで一番古い物はコナンドイルの『緋色の研究』です。あの、シャーロックホームズとワトソン博士が出会う話です。緋色の習作
![post-title](https://i.ytimg.com/vi/sf6JWWxvFHM/hqdefault.jpg)